{"site":{"name":"Longevity Hacker News","canonicalUrl":"https://longevityhackernews.com","description":"Plain-English longevity claim checks on peptides, rapamycin, NAD, biological age testing, gene therapy and biohacking.","aiDisclosure":"AI-assisted editorial summaries with source links, evidence labels and medical-boundary disclosures.","medicalDisclaimer":"Educational only. Not medical advice, diagnosis, treatment, prescribing, dosing, sourcing or emergency guidance."},"topics":[{"slug":"peptides","name":"Peptides","url":"https://longevityhackernews.com/topics/peptides","description":"BPC-157, TB-500, KPV, MOTS-c, GHK-Cu, Semax, Epitalon, CJC-1295, Ipamorelin, Sermorelin and the messy line between approved medicine, compounding and research chemicals."},{"slug":"longevity-drugs","name":"Longevity Drugs","url":"https://longevityhackernews.com/topics/longevity-drugs","description":"Rapamycin, metformin, acarbose, GLP-1s, SGLT2 inhibitors and other drugs discussed as geroprotectors."},{"slug":"nad-supplements-mitochondria","name":"NAD, Supplements & Mitochondria","url":"https://longevityhackernews.com/topics/nad-supplements-mitochondria","description":"NMN, NR, NAD IV, urolithin A, taurine, creatine, CoQ10, spermidine, resveratrol, berberine and mitochondrial health claims."},{"slug":"gene-therapy-reprogramming","name":"Gene Therapy & Reprogramming","url":"https://longevityhackernews.com/topics/gene-therapy-reprogramming","description":"CRISPR, FDA-approved gene therapies, partial epigenetic reprogramming, OSK factors, ER-100, telomerase and the frontier of cellular rejuvenation."},{"slug":"biological-age-biomarkers","name":"Biological Age & Biomarkers","url":"https://longevityhackernews.com/topics/biological-age-biomarkers","description":"Epigenetic clocks, biological age tests, VO2 max, DEXA, CGM, ApoB, Lp(a), HRV, blood panels and quantified-self measurement."},{"slug":"senolytics-cellular-aging","name":"Senolytics & Cellular Aging","url":"https://longevityhackernews.com/topics/senolytics-cellular-aging","description":"Senescent cells, senolytics, fisetin, quercetin, dasatinib, inflammation, immune aging and the hallmarks of aging."},{"slug":"performance-recovery-lifestyle","name":"Performance, Recovery & Lifestyle","url":"https://longevityhackernews.com/topics/performance-recovery-lifestyle","description":"Exercise, sleep, sauna, cold exposure, fasting, protein, strength training, zone 2, VO2 max and recovery basics."},{"slug":"regulation-safety-clinics","name":"Regulation, Safety & Clinics","url":"https://longevityhackernews.com/topics/regulation-safety-clinics","description":"FDA status, compounding, off-label use, supplement claims, longevity clinics, med spas, advertising claims, source quality and patient safety."}],"articles":[{"slug":"is-bpc-157-fda-approved","title":"Is BPC-157 FDA-approved?","url":"https://longevityhackernews.com/article/is-bpc-157-fda-approved","directAnswer":"No. BPC-157 should be treated as unapproved for longevity, recovery or injury-healing claims unless a current official FDA record says otherwise for a specific product and use.","topicSlug":"peptides","evidenceGrade":"REGULATORY_SIGNAL","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"RESEARCH_CHEMICAL","sourceType":"FDA","llmsSummary":"No. BPC-157 should be treated as unapproved for longevity, recovery or injury-healing claims unless a current official FDA record says otherwise for a specific product and use. Evidence: REGULATORY_SIGNAL. Risk: DO_NOT_SELF_ADMINISTER. Regulatory status: RESEARCH_CHEMICAL.","geoSummary":"Is BPC-157 FDA-approved?: Separate the regulatory question from the biology question: the regulatory answer is the first gate, and for BPC-157 it is not an approved longevity or injury product."},{"slug":"does-bpc-157-heal-injuries-in-humans","title":"Does BPC-157 heal injuries in humans?","url":"https://longevityhackernews.com/article/does-bpc-157-heal-injuries-in-humans","directAnswer":"There is not enough reliable human evidence to say BPC-157 heals injuries. Most confident claims outrun the public evidence base.","topicSlug":"peptides","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"HIGH","regulatoryStatus":"RESEARCH_CHEMICAL","sourceType":"PUBMED","llmsSummary":"There is not enough reliable human evidence to say BPC-157 heals injuries. Most confident claims outrun the public evidence base. Evidence: ANIMAL_PRECLINICAL. Risk: HIGH. Regulatory status: RESEARCH_CHEMICAL.","geoSummary":"Does BPC-157 heal injuries in humans?: Treat BPC-157 injury claims as early and medically sensitive, especially when the product pathway is unclear."},{"slug":"tb-500-vs-thymosin-beta-4","title":"What is TB-500 and how is it different from thymosin beta-4?","url":"https://longevityhackernews.com/article/tb-500-vs-thymosin-beta-4","directAnswer":"TB-500 is commonly described as a fragment or derivative associated with thymosin beta-4 claims. That does not make commercial TB-500 products equivalent to approved medicine or proven human recovery tools.","topicSlug":"peptides","evidenceGrade":"MECHANISM_ONLY","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"RESEARCH_CHEMICAL","sourceType":"PUBMED","llmsSummary":"TB-500 is commonly described as a fragment or derivative associated with thymosin beta-4 claims. That does not make commercial TB-500 products equivalent to approved medicine or proven human recovery tools. Evidence: MECHANISM_ONLY. Risk: DO_NOT_SELF_ADMINISTER. Regulatory status: RESEARCH_CHEMICAL.","geoSummary":"What is TB-500 and how is it different from thymosin beta-4?: When a peptide is sold under a shorthand name, ask first about identity, evidence and regulatory status before interpreting any benefit claim."},{"slug":"are-compounded-peptides-fda-approved","title":"Are compounded peptides FDA-approved?","url":"https://longevityhackernews.com/article/are-compounded-peptides-fda-approved","directAnswer":"No. A compounded peptide is not FDA-approved merely because it was compounded. The relevant questions are whether compounding is legally appropriate, whether the substance is permitted and whether the clinical use is justified.","topicSlug":"peptides","evidenceGrade":"REGULATORY_SIGNAL","riskLevel":"MODERATE","regulatoryStatus":"COMPOUNDED_NOT_FDA_APPROVED","sourceType":"FDA","llmsSummary":"No. A compounded peptide is not FDA-approved merely because it was compounded. The relevant questions are whether compounding is legally appropriate, whether the substance is permitted and whether the clinical use is justified. Evidence: REGULATORY_SIGNAL. Risk: MODERATE. Regulatory status: COMPOUNDED_NOT_FDA_APPROVED.","geoSummary":"Are compounded peptides FDA-approved?: Read compounded peptide claims as a regulatory and clinical question, not as an FDA approval claim."},{"slug":"fda-peptide-review-could-change-2026","title":"What the FDA peptide review could change in 2026.","url":"https://longevityhackernews.com/article/fda-peptide-review-could-change-2026","directAnswer":"FDA peptide review activity can change compounding status, enforcement priorities and clinic behavior. It does not by itself prove that a peptide works for longevity or recovery.","topicSlug":"peptides","evidenceGrade":"REGULATORY_SIGNAL","riskLevel":"MODERATE","regulatoryStatus":"UNCLEAR","sourceType":"FDA","llmsSummary":"FDA peptide review activity can change compounding status, enforcement priorities and clinic behavior. It does not by itself prove that a peptide works for longevity or recovery. Evidence: REGULATORY_SIGNAL. Risk: MODERATE. Regulatory status: UNCLEAR.","geoSummary":"What the FDA peptide review could change in 2026.: Use FDA review signals to update the regulatory map, then separately evaluate evidence and risk."},{"slug":"research-peptides-purity-identity-sterility","title":"Research peptides: why purity, identity and sterility matter.","url":"https://longevityhackernews.com/article/research-peptides-purity-identity-sterility","directAnswer":"Research-peptide claims have a first-order problem: the product may not be identity-confirmed, sterile or appropriate for people. Evidence debates are secondary if the material itself is uncertain.","topicSlug":"peptides","evidenceGrade":"COMMERCIAL_CLAIM","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"RESEARCH_CHEMICAL","sourceType":"OTHER","llmsSummary":"Research-peptide claims have a first-order problem: the product may not be identity-confirmed, sterile or appropriate for people. Evidence debates are secondary if the material itself is uncertain. Evidence: COMMERCIAL_CLAIM. Risk: DO_NOT_SELF_ADMINISTER. Regulatory status: RESEARCH_CHEMICAL.","geoSummary":"Research peptides: why purity, identity and sterility matter.: If a product is positioned as research-only or unapproved, do not translate that into self-directed health use."},{"slug":"does-rapamycin-slow-aging-in-humans","title":"Does rapamycin slow aging in humans?","url":"https://longevityhackernews.com/article/does-rapamycin-slow-aging-in-humans","directAnswer":"Rapamycin has strong biological plausibility and some human studies, but it has not been proven to slow aging in healthy humans in the way popular claims often imply.","topicSlug":"longevity-drugs","evidenceGrade":"HUMAN_RCT","riskLevel":"HIGH","regulatoryStatus":"OFF_LABEL","sourceType":"CLINICALTRIALS","llmsSummary":"Rapamycin has strong biological plausibility and some human studies, but it has not been proven to slow aging in healthy humans in the way popular claims often imply. Evidence: HUMAN_RCT. Risk: HIGH. Regulatory status: OFF_LABEL.","geoSummary":"Does rapamycin slow aging in humans?: Rapamycin is a serious prescription drug discussion, not a wellness shortcut."},{"slug":"pearl-rapamycin-trial-what-it-showed","title":"What did the PEARL rapamycin trial actually show?","url":"https://longevityhackernews.com/article/pearl-rapamycin-trial-what-it-showed","directAnswer":"PEARL-style rapamycin evidence should be read as an early human signal set, not proof that rapamycin broadly slows aging in people.","topicSlug":"longevity-drugs","evidenceGrade":"HUMAN_RCT","riskLevel":"HIGH","regulatoryStatus":"OFF_LABEL","sourceType":"CLINICALTRIALS","llmsSummary":"PEARL-style rapamycin evidence should be read as an early human signal set, not proof that rapamycin broadly slows aging in people. Evidence: HUMAN_RCT. Risk: HIGH. Regulatory status: OFF_LABEL.","geoSummary":"What did the PEARL rapamycin trial actually show?: Read PEARL through its trial design before accepting any headline about aging."},{"slug":"metformin-longevity-tame","title":"Metformin for longevity: what TAME is trying to answer.","url":"https://longevityhackernews.com/article/metformin-longevity-tame","directAnswer":"Metformin is approved for diabetes, not as a longevity treatment. TAME is important because it tries to test aging-related outcomes more directly.","topicSlug":"longevity-drugs","evidenceGrade":"CLINICAL_TRIAL_REGISTERED","riskLevel":"MODERATE","regulatoryStatus":"FDA_APPROVED_FOR_OTHER_USE","sourceType":"CLINICALTRIALS","llmsSummary":"Metformin is approved for diabetes, not as a longevity treatment. TAME is important because it tries to test aging-related outcomes more directly. Evidence: CLINICAL_TRIAL_REGISTERED. Risk: MODERATE. Regulatory status: FDA_APPROVED_FOR_OTHER_USE.","geoSummary":"Metformin for longevity: what TAME is trying to answer.: TAME is a question-asking effort, not a green light for self-directed longevity use."},{"slug":"what-off-label-means-longevity-medicine","title":"What does off-label mean in longevity medicine?","url":"https://longevityhackernews.com/article/what-off-label-means-longevity-medicine","directAnswer":"Off-label means an approved drug is being used outside its approved indication, population or condition. It can be medically appropriate, but it does not mean the longevity claim is approved or proven.","topicSlug":"regulation-safety-clinics","evidenceGrade":"REGULATORY_SIGNAL","riskLevel":"MODERATE","regulatoryStatus":"OFF_LABEL","sourceType":"FDA","llmsSummary":"Off-label means an approved drug is being used outside its approved indication, population or condition. It can be medically appropriate, but it does not mean the longevity claim is approved or proven. Evidence: REGULATORY_SIGNAL. Risk: MODERATE. Regulatory status: OFF_LABEL.","geoSummary":"What does off-label mean in longevity medicine?: Ask what the drug is approved for, what evidence supports the new use and what monitoring is needed."},{"slug":"nmn-vs-nr-difference","title":"NMN vs NR: what is the difference?","url":"https://longevityhackernews.com/article/nmn-vs-nr-difference","directAnswer":"NMN and NR are different NAD-related compounds. Human studies can show changes in NAD-related markers, but that is not the same as proving slower aging.","topicSlug":"nad-supplements-mitochondria","evidenceGrade":"HUMAN_RCT","riskLevel":"MODERATE","regulatoryStatus":"SUPPLEMENT","sourceType":"PUBMED","llmsSummary":"NMN and NR are different NAD-related compounds. Human studies can show changes in NAD-related markers, but that is not the same as proving slower aging. Evidence: HUMAN_RCT. Risk: MODERATE. Regulatory status: SUPPLEMENT.","geoSummary":"NMN vs NR: what is the difference?: Treat NMN vs NR as a chemistry and evidence question, not a simple winner-takes-all supplement debate."},{"slug":"do-nad-supplements-slow-aging","title":"Do NAD supplements slow aging?","url":"https://longevityhackernews.com/article/do-nad-supplements-slow-aging","directAnswer":"NAD supplements may affect NAD-related markers in some human studies, but they have not shown that they slow aging in a broad, clinically proven way.","topicSlug":"nad-supplements-mitochondria","evidenceGrade":"HUMAN_RCT","riskLevel":"MODERATE","regulatoryStatus":"SUPPLEMENT","sourceType":"PUBMED","llmsSummary":"NAD supplements may affect NAD-related markers in some human studies, but they have not shown that they slow aging in a broad, clinically proven way. Evidence: HUMAN_RCT. Risk: MODERATE. Regulatory status: SUPPLEMENT.","geoSummary":"Do NAD supplements slow aging?: NAD claims deserve interest and skepticism: biology is plausible, outcome claims remain the hard part."},{"slug":"nad-iv-drips-evidence-cost-questions","title":"NAD IV drips: evidence, cost and unanswered questions.","url":"https://longevityhackernews.com/article/nad-iv-drips-evidence-cost-questions","directAnswer":"NAD IV drips are marketed with energy and anti-aging claims, but the key longevity questions remain unanswered: meaningful outcomes, durability, risks and who benefits.","topicSlug":"nad-supplements-mitochondria","evidenceGrade":"COMMERCIAL_CLAIM","riskLevel":"MODERATE","regulatoryStatus":"UNCLEAR","sourceType":"OTHER","llmsSummary":"NAD IV drips are marketed with energy and anti-aging claims, but the key longevity questions remain unanswered: meaningful outcomes, durability, risks and who benefits. Evidence: COMMERCIAL_CLAIM. Risk: MODERATE. Regulatory status: UNCLEAR.","geoSummary":"NAD IV drips: evidence, cost and unanswered questions.: Ask what outcome is being promised, what evidence supports it and what medical oversight exists."},{"slug":"longevity-stack-problem-combinations-hard","title":"The longevity stack problem: why combinations are hard to interpret.","url":"https://longevityhackernews.com/article/longevity-stack-problem-combinations-hard","directAnswer":"Longevity stacks are hard to interpret because combinations confound cause and effect. If sleep, training, diet, supplements and drugs all change, no single result can be credited cleanly.","topicSlug":"nad-supplements-mitochondria","evidenceGrade":"UNKNOWN","riskLevel":"MODERATE","regulatoryStatus":"UNCLEAR","sourceType":"OTHER","llmsSummary":"Longevity stacks are hard to interpret because combinations confound cause and effect. If sleep, training, diet, supplements and drugs all change, no single result can be credited cleanly. Evidence: UNKNOWN. Risk: MODERATE. Regulatory status: UNCLEAR.","geoSummary":"The longevity stack problem: why combinations are hard to interpret.: If a claim relies on a stack, downgrade certainty and ask what changed, when and compared with what."},{"slug":"is-age-reversal-gene-therapy-real","title":"Is age-reversal gene therapy real?","url":"https://longevityhackernews.com/article/is-age-reversal-gene-therapy-real","directAnswer":"Gene therapy is real, but age-reversal gene therapy for consumers is not established medicine. Treat broad age-reversal claims as investigational unless tied to approved disease-specific products.","topicSlug":"gene-therapy-reprogramming","evidenceGrade":"MECHANISM_ONLY","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"INVESTIGATIONAL","sourceType":"FDA","llmsSummary":"Gene therapy is real, but age-reversal gene therapy for consumers is not established medicine. Treat broad age-reversal claims as investigational unless tied to approved disease-specific products. Evidence: MECHANISM_ONLY. Risk: DO_NOT_SELF_ADMINISTER. Regulatory status: INVESTIGATIONAL.","geoSummary":"Is age-reversal gene therapy real?: Keep approved disease gene therapy separate from speculative longevity gene therapy."},{"slug":"partial-epigenetic-reprogramming","title":"What is partial epigenetic reprogramming?","url":"https://longevityhackernews.com/article/partial-epigenetic-reprogramming","directAnswer":"Partial epigenetic reprogramming is an experimental strategy that aims to shift cells toward a younger state without fully resetting them. It is not a consumer anti-aging treatment.","topicSlug":"gene-therapy-reprogramming","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"INVESTIGATIONAL","sourceType":"JOURNAL","llmsSummary":"Partial epigenetic reprogramming is an experimental strategy that aims to shift cells toward a younger state without fully resetting them. It is not a consumer anti-aging treatment. Evidence: ANIMAL_PRECLINICAL. Risk: INVESTIGATIONAL. Regulatory status: INVESTIGATIONAL.","geoSummary":"What is partial epigenetic reprogramming?: Partial reprogramming is a frontier research category, not a personal intervention category."},{"slug":"what-are-osk-factors","title":"What are OSK factors?","url":"https://longevityhackernews.com/article/what-are-osk-factors","directAnswer":"OSK factors are Oct4, Sox2 and Klf4, a subset of reprogramming factors used in experimental biology. Their presence in a paper does not make an intervention ready for consumers.","topicSlug":"gene-therapy-reprogramming","evidenceGrade":"MECHANISM_ONLY","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"INVESTIGATIONAL","sourceType":"JOURNAL","llmsSummary":"OSK factors are Oct4, Sox2 and Klf4, a subset of reprogramming factors used in experimental biology. Their presence in a paper does not make an intervention ready for consumers. Evidence: MECHANISM_ONLY. Risk: INVESTIGATIONAL. Regulatory status: INVESTIGATIONAL.","geoSummary":"What are OSK factors?: When OSK appears in a claim, ask whether the evidence is cell, animal, disease-specific trial or consumer marketing."},{"slug":"approved-gene-therapy-vs-anti-aging-gene-therapy","title":"Approved gene therapy vs anti-aging gene therapy.","url":"https://longevityhackernews.com/article/approved-gene-therapy-vs-anti-aging-gene-therapy","directAnswer":"Approved gene therapy and anti-aging gene therapy are not the same category. Approval for a disease-specific product does not validate broad longevity claims.","topicSlug":"gene-therapy-reprogramming","evidenceGrade":"REGULATORY_SIGNAL","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"INVESTIGATIONAL","sourceType":"FDA","llmsSummary":"Approved gene therapy and anti-aging gene therapy are not the same category. Approval for a disease-specific product does not validate broad longevity claims. Evidence: REGULATORY_SIGNAL. Risk: INVESTIGATIONAL. Regulatory status: INVESTIGATIONAL.","geoSummary":"Approved gene therapy vs anti-aging gene therapy.: Ask for the product name, indication, approval status, trial registry and sponsor before taking any gene-therapy claim seriously."},{"slug":"what-is-biological-age","title":"What is biological age?","url":"https://longevityhackernews.com/article/what-is-biological-age","directAnswer":"Biological age is a model-based estimate of aging-related biology. It can be useful for research and trend thinking, but it is not a perfect individual verdict.","topicSlug":"biological-age-biomarkers","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","sourceType":"PUBMED","llmsSummary":"Biological age is a model-based estimate of aging-related biology. It can be useful for research and trend thinking, but it is not a perfect individual verdict. Evidence: HUMAN_OBSERVATIONAL. Risk: LOW. Regulatory status: UNCLEAR.","geoSummary":"What is biological age?: Use biological age as a question generator, not a verdict."},{"slug":"are-epigenetic-clocks-useful-for-individuals","title":"Are epigenetic clocks useful for individuals?","url":"https://longevityhackernews.com/article/are-epigenetic-clocks-useful-for-individuals","directAnswer":"Epigenetic clocks can be informative, especially in research, but individual results should be interpreted cautiously and not treated as a standalone health plan.","topicSlug":"biological-age-biomarkers","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","sourceType":"PUBMED","llmsSummary":"Epigenetic clocks can be informative, especially in research, but individual results should be interpreted cautiously and not treated as a standalone health plan. Evidence: HUMAN_OBSERVATIONAL. Risk: LOW. Regulatory status: UNCLEAR.","geoSummary":"Are epigenetic clocks useful for individuals?: A clock result can start a conversation, but conventional risk markers and clinician context still matter."},{"slug":"longevity-biomarker-map","title":"The longevity biomarker map: VO2 max, ApoB, CGM, DEXA and HRV.","url":"https://longevityhackernews.com/article/longevity-biomarker-map","directAnswer":"The best longevity biomarker map separates validated clinical risk markers from fitness measures and exploratory consumer metrics. They should not all be treated equally.","topicSlug":"biological-age-biomarkers","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","sourceType":"NIH","llmsSummary":"The best longevity biomarker map separates validated clinical risk markers from fitness measures and exploratory consumer metrics. They should not all be treated equally. Evidence: HUMAN_OBSERVATIONAL. Risk: LOW. Regulatory status: UNCLEAR.","geoSummary":"The longevity biomarker map: VO2 max, ApoB, CGM, DEXA and HRV.: Prioritize markers with strong outcome links and clear action pathways before chasing exotic scores."},{"slug":"what-are-senescent-cells","title":"What are senescent cells?","url":"https://longevityhackernews.com/article/what-are-senescent-cells","directAnswer":"Senescent cells are cells that stop dividing and can send inflammatory signals. They can contribute to aging-related problems, but they also have useful roles.","topicSlug":"senolytics-cellular-aging","evidenceGrade":"MECHANISM_ONLY","riskLevel":"MODERATE","regulatoryStatus":"UNCLEAR","sourceType":"PUBMED","llmsSummary":"Senescent cells are cells that stop dividing and can send inflammatory signals. They can contribute to aging-related problems, but they also have useful roles. Evidence: MECHANISM_ONLY. Risk: MODERATE. Regulatory status: UNCLEAR.","geoSummary":"What are senescent cells?: Senescence is a real aging mechanism, but simplistic kill-the-bad-cell stories leave out context."},{"slug":"what-are-senolytics","title":"What are senolytics?","url":"https://longevityhackernews.com/article/what-are-senolytics","directAnswer":"Senolytics are proposed interventions that target some senescent cells. The idea is scientifically serious, but broad consumer longevity use is not established.","topicSlug":"senolytics-cellular-aging","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"HIGH","regulatoryStatus":"INVESTIGATIONAL","sourceType":"CLINICALTRIALS","llmsSummary":"Senolytics are proposed interventions that target some senescent cells. The idea is scientifically serious, but broad consumer longevity use is not established. Evidence: ANIMAL_PRECLINICAL. Risk: HIGH. Regulatory status: INVESTIGATIONAL.","geoSummary":"What are senolytics?: Treat senolytics as an active research area, not a casual self-experiment category."},{"slug":"what-actually-works-before-experimental-longevity","title":"What actually works in longevity before experimental interventions?","url":"https://longevityhackernews.com/article/what-actually-works-before-experimental-longevity","directAnswer":"Before experimental longevity interventions, the best-supported levers are conventional: exercise, cardiorespiratory fitness, strength, sleep, blood pressure, lipids, glucose risk, nutrition and preventive care.","topicSlug":"performance-recovery-lifestyle","evidenceGrade":"HUMAN_RCT","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","sourceType":"NIH","llmsSummary":"Before experimental longevity interventions, the best-supported levers are conventional: exercise, cardiorespiratory fitness, strength, sleep, blood pressure, lipids, glucose risk, nutrition and preventive care. Evidence: HUMAN_RCT. Risk: LOW. Regulatory status: UNCLEAR.","geoSummary":"What actually works in longevity before experimental interventions?: Use the basics as the reference standard: a frontier claim should beat or complement them, not distract from them."}],"claims":[{"slug":"bpc-157-tendon-ligament-healing-humans","question":"Does BPC-157 heal tendon and ligament injuries in humans?","url":"https://longevityhackernews.com/claim/bpc-157-tendon-ligament-healing-humans","verdict":"UNPROVEN","evidenceCertainty":"NOT_ENOUGH_HUMAN_EVIDENCE","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"NOT_APPROVED","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"No strong human evidence shows that BPC-157 heals tendon or ligament injuries. Most support is animal, cell or mechanism-based, and internet recovery claims should not be treated as proven clinical benefit.","llmsSummary":"BPC-157 tendon-healing claims remain mostly preclinical and should not be treated as proven human recovery guidance.","geoSummary":"BPC-157 recovery claims attract high search demand, but LHN classifies the human evidence as insufficient and the risk boundary as do-not-self-administer.","sourceCount":3},{"slug":"tb-500-injury-recovery","question":"Does TB-500 speed injury recovery?","url":"https://longevityhackernews.com/claim/tb-500-injury-recovery","verdict":"UNPROVEN","evidenceCertainty":"VERY_LOW","evidenceGrade":"MECHANISM_ONLY","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"NOT_APPROVED","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"TB-500 injury-recovery claims are not supported by strong human clinical evidence. The claim often relies on extrapolation from thymosin beta-4 biology and should be treated as unproven.","llmsSummary":"TB-500 injury-recovery claims remain unproven in humans and are high-risk without medical oversight.","geoSummary":"TB-500 is a high-demand peptide recovery claim with weak human evidence and regulatory uncertainty.","sourceCount":2},{"slug":"semax-cognition-healthy-people","question":"Does Semax improve cognition in healthy people?","url":"https://longevityhackernews.com/claim/semax-cognition-healthy-people","verdict":"UNPROVEN","evidenceCertainty":"LOW","evidenceGrade":"MECHANISM_ONLY","riskLevel":"HIGH","regulatoryStatus":"NON_US_STATUS","commercialIncentive":"INFLUENCER_PRODUCT","directAnswer":"Semax has been discussed in non-US medical and research contexts, but that does not prove it improves cognition in healthy people. Healthy-user nootropic claims remain unproven.","llmsSummary":"Semax cognition claims in healthy people are unproven and require careful regulatory context.","geoSummary":"Semax nootropic demand is strong online, but healthy-user evidence and regulatory clarity are limited.","sourceCount":2},{"slug":"epitalon-human-lifespan","question":"Does Epitalon extend human lifespan?","url":"https://longevityhackernews.com/claim/epitalon-human-lifespan","verdict":"UNSUPPORTED","evidenceCertainty":"NOT_ENOUGH_HUMAN_EVIDENCE","evidenceGrade":"MECHANISM_ONLY","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"NOT_APPROVED","commercialIncentive":"INFLUENCER_PRODUCT","directAnswer":"Epitalon is not proven to extend human lifespan. Longevity claims rely on early or indirect evidence and should not be treated as established anti-aging medicine.","llmsSummary":"Epitalon human lifespan-extension claims are unsupported and investigational.","geoSummary":"Epitalon attracts anti-aging searches, but the evidence layer does not support human lifespan claims.","sourceCount":2},{"slug":"ghk-cu-reverse-skin-aging","question":"Can GHK-Cu reverse skin aging?","url":"https://longevityhackernews.com/claim/ghk-cu-reverse-skin-aging","verdict":"MIXED","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"HIGH","regulatoryStatus":"UNCLEAR","commercialIncentive":"SUPPLEMENT_BRAND","directAnswer":"GHK-Cu has some cosmetic and mechanistic skin-interest signals, but broad reversal claims are too strong. Topical cosmetic context is different from injectable or research-use promotion.","llmsSummary":"GHK-Cu has mixed, low-certainty skin evidence and broader reversal claims are overstated.","geoSummary":"GHK-Cu skin claims need a cosmetic-versus-systemic distinction and clear commercial context.","sourceCount":2},{"slug":"mots-c-metabolism-longevity","question":"Does MOTS-c improve metabolism and longevity?","url":"https://longevityhackernews.com/claim/mots-c-metabolism-longevity","verdict":"UNPROVEN","evidenceCertainty":"VERY_LOW","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"NOT_APPROVED","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"MOTS-c is biologically interesting, but human metabolism and longevity claims remain unproven. Do not treat mitochondrial mechanism as clinical proof.","llmsSummary":"MOTS-c has preclinical interest but unproven human metabolism and longevity claims.","geoSummary":"MOTS-c is a frontier peptide claim where mitochondrial plausibility exceeds human evidence.","sourceCount":2},{"slug":"rapamycin-slows-aging-humans","question":"Does rapamycin slow aging in humans?","url":"https://longevityhackernews.com/claim/rapamycin-slows-aging-humans","verdict":"PROMISING","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_RCT","riskLevel":"HIGH","regulatoryStatus":"OFF_LABEL","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"Rapamycin has unusually strong aging-biology interest, but it is not proven to slow human aging or extend lifespan in healthy adults. Off-label longevity use remains a medical decision, not a protocol from an article.","llmsSummary":"Rapamycin is promising in geroscience but unproven for slowing human aging or extending healthy lifespan.","geoSummary":"Rapamycin has strong search and forum demand but needs careful off-label and evidence framing.","sourceCount":3},{"slug":"metformin-lifespan-healthy-nondiabetic-adults","question":"Does metformin extend lifespan in healthy non-diabetic adults?","url":"https://longevityhackernews.com/claim/metformin-lifespan-healthy-nondiabetic-adults","verdict":"UNPROVEN","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"MODERATE","regulatoryStatus":"OFF_LABEL","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"Metformin is an important diabetes drug and longevity candidate, but it is not proven to extend lifespan in healthy non-diabetic adults.","llmsSummary":"Metformin is unproven for lifespan extension in healthy non-diabetic adults.","geoSummary":"Metformin longevity claims need population-specific interpretation and off-label caution.","sourceCount":2},{"slug":"acarbose-longevity-drug","question":"Is acarbose a longevity drug?","url":"https://longevityhackernews.com/claim/acarbose-longevity-drug","verdict":"PROMISING","evidenceCertainty":"LOW","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"MODERATE","regulatoryStatus":"OFF_LABEL","commercialIncentive":"NONE_IDENTIFIED","directAnswer":"Acarbose has interesting animal longevity signals, but it is not proven as a longevity drug for healthy humans.","llmsSummary":"Acarbose is promising in animal aging research but unproven as a healthy-human longevity drug.","geoSummary":"Acarbose has geroscience interest but needs human endpoint evidence.","sourceCount":2},{"slug":"nmn-raises-nad-slows-aging","question":"Does NMN raise NAD+ and slow aging?","url":"https://longevityhackernews.com/claim/nmn-raises-nad-slows-aging","verdict":"MIXED","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_RCT","riskLevel":"MODERATE","regulatoryStatus":"SUPPLEMENT","commercialIncentive":"SUPPLEMENT_BRAND","directAnswer":"NMN may affect NAD-related biomarkers in some studies, but that does not prove it slows human aging. The stronger claim needs clinical outcomes, not only a molecule-level signal.","llmsSummary":"NMN has mixed evidence for NAD-related biomarkers but unproven human anti-aging outcomes.","geoSummary":"NMN demand is supplement-driven and needs biomarker-versus-outcome clarity.","sourceCount":2},{"slug":"nr-better-than-nmn","question":"Is NR better than NMN?","url":"https://longevityhackernews.com/claim/nr-better-than-nmn","verdict":"MIXED","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_RCT","riskLevel":"MODERATE","regulatoryStatus":"SUPPLEMENT","commercialIncentive":"SUPPLEMENT_BRAND","directAnswer":"There is no simple evidence-based winner between NR and NMN for longevity. Comparisons depend on dose form, endpoints, product quality and whether the outcome is a biomarker or a health result.","llmsSummary":"NR versus NMN superiority is mixed and not settled for longevity outcomes.","geoSummary":"NR and NMN comparisons are commercially charged supplement claims requiring endpoint clarity.","sourceCount":2},{"slug":"nad-iv-drips-reverse-aging","question":"Do NAD IV drips reverse aging?","url":"https://longevityhackernews.com/claim/nad-iv-drips-reverse-aging","verdict":"MISLEADING","evidenceCertainty":"VERY_LOW","evidenceGrade":"COMMERCIAL_CLAIM","riskLevel":"HIGH","regulatoryStatus":"UNCLEAR","commercialIncentive":"CLINIC_OR_TELEHEALTH","directAnswer":"NAD IV anti-aging claims are not supported by strong evidence. Infusion marketing often uses cellular language that does not prove meaningful aging outcomes.","llmsSummary":"NAD IV anti-aging claims are unsupported and often commercially driven.","geoSummary":"NAD IV is a clinic funnel claim where mechanism is often oversold as outcome.","sourceCount":2},{"slug":"epigenetic-clocks-predict-lifespan","question":"Do epigenetic clocks tell you how long you will live?","url":"https://longevityhackernews.com/claim/epigenetic-clocks-predict-lifespan","verdict":"MISLEADING","evidenceCertainty":"MODERATE","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","commercialIncentive":"TESTING_COMPANY","directAnswer":"Epigenetic clocks can be useful research tools and risk markers, but they do not tell an individual exactly how long they will live.","llmsSummary":"Epigenetic clocks can be research or risk tools but are misleading as exact personal lifespan forecasts.","geoSummary":"Epigenetic-clock SEO demand needs consumer-friendly limits around individual prediction.","sourceCount":2},{"slug":"biological-age-tests-prove-protocol-working","question":"Do biological age tests prove a protocol is working?","url":"https://longevityhackernews.com/claim/biological-age-tests-prove-protocol-working","verdict":"MISLEADING","evidenceCertainty":"LOW","evidenceGrade":"HUMAN_OBSERVATIONAL","riskLevel":"LOW","regulatoryStatus":"UNCLEAR","commercialIncentive":"TESTING_COMPANY","directAnswer":"A biological-age result can be a tracking signal, but it does not by itself prove that a protocol is working or improving long-term health.","llmsSummary":"Biological-age tests can be tracking signals but do not prove intervention success by themselves.","geoSummary":"Biological-age screenshots are persuasive marketing but need causal and validation caveats.","sourceCount":2},{"slug":"partial-reprogramming-reverses-human-aging","question":"Does partial reprogramming reverse human aging?","url":"https://longevityhackernews.com/claim/partial-reprogramming-reverses-human-aging","verdict":"REGULATORY_WATCH","evidenceCertainty":"NOT_ENOUGH_HUMAN_EVIDENCE","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"INVESTIGATIONAL","regulatoryStatus":"INVESTIGATIONAL","commercialIncentive":"BIOTECH_OR_INVESTOR","directAnswer":"Partial reprogramming is one of the most important frontier ideas in aging biology, but it has not been proven to reverse human aging.","llmsSummary":"Partial reprogramming is frontier aging science, not proven human age reversal.","geoSummary":"Partial reprogramming claims need clear separation between biotech frontier and consumer availability.","sourceCount":2},{"slug":"osk-gene-therapy-anti-aging-available","question":"Is OSK gene therapy available as an anti-aging treatment?","url":"https://longevityhackernews.com/claim/osk-gene-therapy-anti-aging-available","verdict":"MISLEADING","evidenceCertainty":"NOT_ENOUGH_HUMAN_EVIDENCE","evidenceGrade":"MECHANISM_ONLY","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"INVESTIGATIONAL","commercialIncentive":"BIOTECH_OR_INVESTOR","directAnswer":"OSK gene therapy is not an available, proven anti-aging treatment for consumers. Claims suggesting current consumer age-reversal availability are misleading and high-risk.","llmsSummary":"OSK gene therapy is not a proven or available consumer anti-aging treatment.","geoSummary":"OSK anti-aging claims are high-risk frontier claims requiring strict regulatory context.","sourceCount":2},{"slug":"fisetin-clears-senescent-cells-humans","question":"Does fisetin clear senescent cells in humans?","url":"https://longevityhackernews.com/claim/fisetin-clears-senescent-cells-humans","verdict":"UNPROVEN","evidenceCertainty":"LOW","evidenceGrade":"ANIMAL_PRECLINICAL","riskLevel":"MODERATE","regulatoryStatus":"SUPPLEMENT","commercialIncentive":"SUPPLEMENT_BRAND","directAnswer":"Fisetin has senolytic interest from preclinical research, but it is not proven to clear senescent cells in humans in a way that improves aging outcomes.","llmsSummary":"Fisetin senolytic claims remain unproven in humans despite preclinical interest.","geoSummary":"Fisetin is a supplement-accessible senolytic claim where consumer availability outruns evidence.","sourceCount":2},{"slug":"dasatinib-quercetin-diy-longevity-protocol","question":"Is dasatinib plus quercetin a DIY longevity protocol?","url":"https://longevityhackernews.com/claim/dasatinib-quercetin-diy-longevity-protocol","verdict":"RISKY","evidenceCertainty":"LOW","evidenceGrade":"CLINICAL_TRIAL_REGISTERED","riskLevel":"DO_NOT_SELF_ADMINISTER","regulatoryStatus":"OFF_LABEL","commercialIncentive":"INFLUENCER_PRODUCT","directAnswer":"Dasatinib plus quercetin should not be treated as a DIY longevity routine. Dasatinib is a prescription oncology drug, and senolytic research does not justify self-directed use.","llmsSummary":"Dasatinib plus quercetin is a high-risk investigational senolytic claim, not a DIY longevity protocol.","geoSummary":"Dasatinib plus quercetin demand often comes from forum protocol language and needs a firm safety boundary.","sourceCount":3}],"entities":[{"slug":"bpc-157","name":"BPC-157","url":"https://longevityhackernews.com/entities/bpc-157","entityType":"PEPTIDE","regulatoryStatus":"NOT_APPROVED","riskLevel":"DO_NOT_SELF_ADMINISTER","evidenceSummary":"Mostly preclinical or indirect for the popular injury-recovery claim."},{"slug":"tb-500","name":"TB-500","url":"https://longevityhackernews.com/entities/tb-500","entityType":"PEPTIDE","regulatoryStatus":"NOT_APPROVED","riskLevel":"DO_NOT_SELF_ADMINISTER","evidenceSummary":"Human evidence for consumer recovery claims is weak."},{"slug":"semax","name":"Semax","url":"https://longevityhackernews.com/entities/semax","entityType":"PEPTIDE","regulatoryStatus":"NON_US_STATUS","riskLevel":"HIGH","evidenceSummary":"Evidence is not strong enough for healthy-person cognition claims."},{"slug":"epitalon","name":"Epitalon","url":"https://longevityhackernews.com/entities/epitalon","entityType":"PEPTIDE","regulatoryStatus":"NOT_APPROVED","riskLevel":"INVESTIGATIONAL","evidenceSummary":"Human lifespan claims are unsupported."},{"slug":"ghk-cu","name":"GHK-Cu","url":"https://longevityhackernews.com/entities/ghk-cu","entityType":"PEPTIDE","regulatoryStatus":"UNCLEAR","riskLevel":"HIGH","evidenceSummary":"Mixed low-certainty evidence for skin appearance; broader anti-aging claims are overstated."},{"slug":"mots-c","name":"MOTS-c","url":"https://longevityhackernews.com/entities/mots-c","entityType":"PEPTIDE","regulatoryStatus":"NOT_APPROVED","riskLevel":"INVESTIGATIONAL","evidenceSummary":"Preclinical interest exceeds human outcome evidence."},{"slug":"rapamycin","name":"Rapamycin","url":"https://longevityhackernews.com/entities/rapamycin","entityType":"DRUG","regulatoryStatus":"OFF_LABEL","riskLevel":"HIGH","evidenceSummary":"Promising biology and animal data; human aging endpoints remain unproven."},{"slug":"metformin","name":"Metformin","url":"https://longevityhackernews.com/entities/metformin","entityType":"DRUG","regulatoryStatus":"OFF_LABEL","riskLevel":"MODERATE","evidenceSummary":"Observational signals are interesting but healthy-adult lifespan claims are unproven."},{"slug":"acarbose","name":"Acarbose","url":"https://longevityhackernews.com/entities/acarbose","entityType":"DRUG","regulatoryStatus":"OFF_LABEL","riskLevel":"MODERATE","evidenceSummary":"Animal signals are promising; human longevity evidence is not established."},{"slug":"nad","name":"NAD+","url":"https://longevityhackernews.com/entities/nad","entityType":"MECHANISM","regulatoryStatus":"UNCLEAR","riskLevel":"MODERATE","evidenceSummary":"Biomarker effects do not automatically establish anti-aging outcomes."},{"slug":"nmn","name":"NMN","url":"https://longevityhackernews.com/entities/nmn","entityType":"SUPPLEMENT","regulatoryStatus":"SUPPLEMENT","riskLevel":"MODERATE","evidenceSummary":"Mixed for biomarkers; unproven for slowing human aging."},{"slug":"nr","name":"NR","url":"https://longevityhackernews.com/entities/nr","entityType":"SUPPLEMENT","regulatoryStatus":"SUPPLEMENT","riskLevel":"MODERATE","evidenceSummary":"Human biomarker evidence exists, but longevity superiority is unproven."},{"slug":"epigenetic-clocks","name":"Epigenetic clocks","url":"https://longevityhackernews.com/entities/epigenetic-clocks","entityType":"TEST","regulatoryStatus":"UNCLEAR","riskLevel":"LOW","evidenceSummary":"Useful population-level associations; individual decision utility remains more limited."},{"slug":"biological-age","name":"Biological age","url":"https://longevityhackernews.com/entities/biological-age","entityType":"BIOMARKER","regulatoryStatus":"UNCLEAR","riskLevel":"LOW","evidenceSummary":"Measurement quality and clinical usefulness vary widely."},{"slug":"senescent-cells","name":"Senescent cells","url":"https://longevityhackernews.com/entities/senescent-cells","entityType":"MECHANISM","regulatoryStatus":"UNCLEAR","riskLevel":"MODERATE","evidenceSummary":"Strong biology; intervention evidence varies by compound and population."},{"slug":"fisetin","name":"Fisetin","url":"https://longevityhackernews.com/entities/fisetin","entityType":"SUPPLEMENT","regulatoryStatus":"SUPPLEMENT","riskLevel":"MODERATE","evidenceSummary":"Preclinical senolytic interest but limited human outcome evidence."},{"slug":"partial-reprogramming","name":"Partial reprogramming","url":"https://longevityhackernews.com/entities/partial-reprogramming","entityType":"INTERVENTION","regulatoryStatus":"INVESTIGATIONAL","riskLevel":"INVESTIGATIONAL","evidenceSummary":"Preclinical and early research interest; human aging claims unproven."},{"slug":"osk-factors","name":"OSK factors","url":"https://longevityhackernews.com/entities/osk-factors","entityType":"MECHANISM","regulatoryStatus":"INVESTIGATIONAL","riskLevel":"DO_NOT_SELF_ADMINISTER","evidenceSummary":"Mechanistic and preclinical relevance; no consumer anti-aging availability."},{"slug":"fda","name":"FDA","url":"https://longevityhackernews.com/entities/fda","entityType":"REGULATOR","regulatoryStatus":"FDA_APPROVED_FOR_THIS_USE","riskLevel":"LOW","evidenceSummary":"Regulatory documents clarify what is approved, under review, investigational or not approved."},{"slug":"clinicaltrialsgov","name":"ClinicalTrials.gov","url":"https://longevityhackernews.com/entities/clinicaltrialsgov","entityType":"REGULATOR","regulatoryStatus":"UNCLEAR","riskLevel":"LOW","evidenceSummary":"Useful for study status, design and endpoints; not proof of benefit."}],"sourceCatalogSummary":{"total":266,"official":35,"journals":220,"news":8},"sourceCategories":[{"name":"ACS Chemical Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22ACS%20Chemical%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"ACS Pharmacology and Translational Science","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22ACS%20Pharmacology%20and%20Translational%20Science%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Advances in Nutrition","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Advances%20in%20Nutrition%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Age and Ageing","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20and%20Ageing%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Ageing and Society","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Ageing%20and%20Society%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Ageing Research Reviews","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Ageing%20Research%20Reviews%22%5Bjournal%5D","howWeUseIt":"We use 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limitations."},{"name":"bioRxiv","type":"JOURNAL","url":"https://www.biorxiv.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Blood","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Blood%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Blood Advances","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Blood%20Advances%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"BMC Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22BMC%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"BMC 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Pharmacology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22British%20Journal%20of%20Clinical%20Pharmacology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"British Journal of Sports Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22British%20Journal%20of%20Sports%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Business Wire Healthcare","type":"NEWS","url":"https://www.businesswire.com/portal/site/home/news/industry/?vnsId=31407","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Cancer Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer%20Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cancer Discovery","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer%20Discovery%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cancer Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"CDC","type":"OTHER","url":"https://www.cdc.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Death and Differentiation","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Death%20and%20Differentiation%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Death and Disease","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Death%20and%20Disease%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Metabolism","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Metabolism%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Reports","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Reports%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Reports Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Reports%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cell Stem Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell%20Stem%20Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"ChEMBL","type":"OTHER","url":"https://www.ebi.ac.uk/chembl/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Circulation","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Circulation%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical and Translational Science","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20and%20Translational%20Science%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical Cancer Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20Cancer%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical Chemistry","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20Chemistry%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical Chemistry and Laboratory Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20Chemistry%20and%20Laboratory%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical Interventions in Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20Interventions%20in%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Clinical Pharmacology and Therapeutics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Clinical%20Pharmacology%20and%20Therapeutics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"ClinicalTrials.gov","type":"CLINICALTRIALS","url":"https://clinicaltrials.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"ClinVar","type":"NIH","url":"https://www.ncbi.nlm.nih.gov/clinvar/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Cochrane Library","type":"JOURNAL","url":"https://www.cochranelibrary.com/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Cold Spring Harbor Molecular Case Studies","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cold%20Spring%20Harbor%20Molecular%20Case%20Studies%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Cold Spring Harbor Perspectives in Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Cold%20Spring%20Harbor%20Perspectives%20in%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Communications Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Communications%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Communications Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Communications%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"CRISPR Journal","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22CRISPR%20Journal%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Crossref","type":"OTHER","url":"https://www.crossref.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Current Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Current%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Current Opinion in Cell Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Current%20Opinion%20in%20Cell%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Current%20Opinion%20in%20Clinical%20Nutrition%20and%20Metabolic%20Care%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Current Opinion in Genetics and Development","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Current%20Opinion%20in%20Genetics%20and%20Development%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Current Opinion in Pharmacology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Current%20Opinion%20in%20Pharmacology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"DailyMed","type":"NIH","url":"https://dailymed.nlm.nih.gov/dailymed/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Developmental Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Developmental%20Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Diabetes","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Diabetes%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Diabetes Care","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Diabetes%20Care%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Digital Biomarkers","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Digital%20Biomarkers%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Drug Discovery Today","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Drug%20Discovery%20Today%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"DrugBank","type":"OTHER","url":"https://go.drugbank.com/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Drugs and Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Drugs%20and%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"eLife","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22eLife%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"EMA","type":"OTHER","url":"https://www.ema.europa.eu/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"EMBO Journal","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22EMBO%20Journal%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"EMBO Molecular Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22EMBO%20Molecular%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"EMBO Reports","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22EMBO%20Reports%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Endocrine Reviews","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Endocrine%20Reviews%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Endocrinology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Endocrinology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Endpoints News","type":"NEWS","url":"https://endpts.com/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Epigenetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Epigenetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Epigenetics and Chromatin","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Epigenetics%20and%20Chromatin%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"EU Clinical Trials Register","type":"CLINICALTRIALS","url":"https://www.clinicaltrialsregister.eu/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Europe PMC","type":"PUBMED","url":"https://europepmc.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"European Heart Journal","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22European%20Heart%20Journal%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"European Journal of Ageing","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22European%20Journal%20of%20Ageing%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"European Journal of Applied Physiology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22European%20Journal%20of%20Applied%20Physiology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"European Journal of Human Genetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22European%20Journal%20of%20Human%20Genetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Experimental Cell Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Experimental%20Cell%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Experimental Gerontology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Experimental%20Gerontology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"FASEB Journal","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22FASEB%20Journal%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"FDA","type":"FDA","url":"https://www.fda.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"FDA Approved Cellular and Gene Therapy Products","type":"FDA","url":"https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/approved-cellular-and-gene-therapy-products","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"FDA Dietary Supplements","type":"FDA","url":"https://www.fda.gov/food/dietary-supplements","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"FDA Drug Approvals and Databases","type":"FDA","url":"https://www.fda.gov/drugs/development-approval-process-drugs/drug-approvals-and-databases","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"FDA Human Drug Compounding","type":"FDA","url":"https://www.fda.gov/drugs/human-drug-compounding","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Fierce Biotech","type":"NEWS","url":"https://www.fiercebiotech.com/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Fierce Pharma","type":"NEWS","url":"https://www.fiercepharma.com/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Free Radical Biology and Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Free%20Radical%20Biology%20and%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Cell and Developmental Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Cell%20and%20Developmental%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Endocrinology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Endocrinology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Genetics of Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Genetics%20of%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Immunology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Immunology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Molecular Biosciences","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Molecular%20Biosciences%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Nutrition","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Nutrition%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Pharmacology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Pharmacology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Frontiers in Physiology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontiers%20in%20Physiology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Gene Therapy","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Gene%20Therapy%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"GeneReviews","type":"NIH","url":"https://www.ncbi.nlm.nih.gov/books/NBK1116/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Genetics in Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Genetics%20in%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Genome Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Genome%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Genome Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Genome%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Genome Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Genome%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"GenomeWeb","type":"NEWS","url":"https://www.genomeweb.com/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Gerontologist","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Gerontologist%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Gerontology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Gerontology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"GeroScience","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22GeroScience%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Haematologica","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Haematologica%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Health Canada","type":"OTHER","url":"https://www.canada.ca/en/health-canada.html","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Heliyon","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Heliyon%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Human Gene Therapy","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Human%20Gene%20Therapy%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Human Molecular Genetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Human%20Molecular%20Genetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Hypertension","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypertension%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Immunity","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunity%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Innovation in Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Innovation%20in%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"International Journal of Obesity","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22International%20Journal%20of%20Obesity%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"iScience","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22iScience%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"ISRCTN Registry","type":"CLINICALTRIALS","url":"https://www.isrctn.com/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"JAMA","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JAMA%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"JAMA Internal Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JAMA%20Internal%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"JAMA Neurology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JAMA%20Neurology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"JAMA Oncology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JAMA%20Oncology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Japan PMDA","type":"OTHER","url":"https://www.pmda.go.jp/english/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Japan Registry of Clinical Trials","type":"CLINICALTRIALS","url":"https://jrct.niph.go.jp/en-latest-detail","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"JCI Insight","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JCI%20Insight%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"JMIR Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22JMIR%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Aging Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Aging%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Applied Physiology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Applied%20Physiology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Cachexia Sarcopenia and Muscle","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Cachexia%20Sarcopenia%20and%20Muscle%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Cell Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Cell%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Cell Science","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Cell%20Science%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Clinical Endocrinology and Metabolism","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Clinical%20Endocrinology%20and%20Metabolism%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Clinical Investigation","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Clinical%20Investigation%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Gerontology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Gerontology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Medical Internet Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Medical%20Internet%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Medicinal Chemistry","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Medicinal%20Chemistry%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Nutrition","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Nutrition%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Proteome Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Proteome%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Sleep Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Sleep%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of the American College of Cardiology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20the%20American%20College%20of%20Cardiology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Journal of Translational Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Journal%20of%20Translational%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Labiotech","type":"NEWS","url":"https://www.labiotech.eu/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Mechanisms of Ageing and Development","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Mechanisms%20of%20Ageing%20and%20Development%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Medicine and Science in Sports and Exercise","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Medicine%20and%20Science%20in%20Sports%20and%20Exercise%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"medRxiv","type":"JOURNAL","url":"https://www.medrxiv.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Metabolomics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Metabolomics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"MHRA","type":"OTHER","url":"https://www.gov.uk/government/organisations/medicines-and-healthcare-products-regulatory-agency","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Mitochondrion","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitochondrion%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular and Cellular Proteomics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20and%20Cellular%20Proteomics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Aspects of Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Aspects%20of%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Biology of the Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Biology%20of%20the%20Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Cell","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Cell%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Metabolism","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Metabolism%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Neurodegeneration","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Neurodegeneration%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Pharmaceutics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Pharmaceutics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Therapy","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Therapy%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Molecular Therapy Methods and Clinical Development","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Molecular%20Therapy%20Methods%20and%20Clinical%20Development%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"National Institute on Aging","type":"NIH","url":"https://www.nia.nih.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Nature","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Biotechnology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Biotechnology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Cancer","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Cancer%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Communications","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Communications%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Gene Therapy","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Gene%20Therapy%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Genetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Genetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Metabolism","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Metabolism%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Reviews Cardiology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Reviews%20Cardiology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Reviews Drug Discovery","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Reviews%20Drug%20Discovery%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Reviews Endocrinology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Reviews%20Endocrinology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Reviews Genetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Reviews%20Genetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nature Reviews Molecular Cell Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nature%20Reviews%20Molecular%20Cell%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Neurobiology of Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Neurobiology%20of%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Neurology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Neurology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Neuron","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuron%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"New England Journal of Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22New%20England%20Journal%20of%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"NIH","type":"NIH","url":"https://www.nih.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"NIH Office of Dietary Supplements","type":"NIH","url":"https://ods.od.nih.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"NIH RePORTER","type":"NIH","url":"https://reporter.nih.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"npj Aging","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22npj%20Aging%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"NPJ Digital Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22NPJ%20Digital%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nucleic Acids Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nucleic%20Acids%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nutrients","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nutrients%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Nutrition Reviews","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Nutrition%20Reviews%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Obesity","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Obesity%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"OMIM","type":"OTHER","url":"https://www.omim.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Oncogene","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Oncogene%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"OpenAlex","type":"OTHER","url":"https://openalex.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Patterns","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Patterns%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PeerJ","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22PeerJ%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Pharmacological Reviews","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Pharmacological%20Reviews%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PLOS Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22PLOS%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PLOS Genetics","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22PLOS%20Genetics%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PLOS Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22PLOS%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PLOS ONE","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22PLOS%20ONE%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PR Newswire Healthcare","type":"NEWS","url":"https://www.prnewswire.com/news-releases/health-news-latest-news/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Proceedings of the National Academy of Sciences","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Proceedings%20of%20the%20National%20Academy%20of%20Sciences%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Proceedings of the Royal Society B","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Proceedings%20of%20the%20Royal%20Society%20B%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Public Policy and Aging Report","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Public%20Policy%20and%20Aging%20Report%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"PubMed","type":"PUBMED","url":"https://pubmed.ncbi.nlm.nih.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"PubMed Central","type":"PUBMED","url":"https://www.ncbi.nlm.nih.gov/pmc/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Redox Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Redox%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Regenerative Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Regenerative%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Regulatory Toxicology and Pharmacology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Regulatory%20Toxicology%20and%20Pharmacology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Rejuvenation Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Rejuvenation%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Retraction Watch Database","type":"OTHER","url":"https://retractiondatabase.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"RNA","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22RNA%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Royal Society Open Science","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Royal%20Society%20Open%20Science%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"RxNorm","type":"NIH","url":"https://www.nlm.nih.gov/research/umls/rxnorm/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Science","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Science%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Science Advances","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Science%20Advances%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Science Translational Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Science%20Translational%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Scientific Reports","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Scientific%20Reports%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"SEC EDGAR","type":"OTHER","url":"https://www.sec.gov/edgar/search/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"Seminars in Cell and Developmental Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Seminars%20in%20Cell%20and%20Developmental%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Skeletal Muscle","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Skeletal%20Muscle%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Sleep","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Sleep%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Sleep Medicine Reviews","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Sleep%20Medicine%20Reviews%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Sports Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Sports%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"STAT","type":"NEWS","url":"https://www.statnews.com/","howWeUseIt":"We use this for discovery and market signals, then verify claims against primary sources."},{"name":"Stem Cell Reports","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Stem%20Cell%20Reports%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Stem Cells","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Stem%20Cells%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Stem Cells Translational Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Stem%20Cells%20Translational%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Stroke","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Stroke%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Journals of Gerontology Series A","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Journals%20of%20Gerontology%20Series%20A%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Journals of Gerontology Series B","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Journals%20of%20Gerontology%20Series%20B%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Lancet","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Lancet%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Lancet Diabetes and Endocrinology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Lancet%20Diabetes%20and%20Endocrinology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Lancet Digital Health","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Lancet%20Digital%20Health%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Lancet Healthy Longevity","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Lancet%20Healthy%20Longevity%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"The Lancet Oncology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22The%20Lancet%20Oncology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Tissue Engineering Part A","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Tissue%20Engineering%20Part%20A%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Toxicological Sciences","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Toxicological%20Sciences%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Translational Research","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Translational%20Research%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Trends in Cell Biology","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Trends%20in%20Cell%20Biology%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Trends in Endocrinology and Metabolism","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Trends%20in%20Endocrinology%20and%20Metabolism%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Trends in Molecular Medicine","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Trends%20in%20Molecular%20Medicine%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"Trends in Pharmacological Sciences","type":"JOURNAL","url":"https://pubmed.ncbi.nlm.nih.gov/?term=%22Trends%20in%20Pharmacological%20Sciences%22%5Bjournal%5D","howWeUseIt":"We use journal-scoped queries to discover papers, then evaluate the article, authors, methods, endpoints and limitations."},{"name":"UniProt","type":"OTHER","url":"https://www.uniprot.org/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"US Patent and Trademark Office","type":"OTHER","url":"https://www.uspto.gov/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"WHO","type":"OTHER","url":"https://www.who.int/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."},{"name":"WHO ICTRP","type":"CLINICALTRIALS","url":"https://trialsearch.who.int/","howWeUseIt":"We use this to verify source facts, dates, status, terminology and original documents."}]}