Regulatory SignalDo Not Self AdministerResearch Chemical
Is BPC-157 FDA-approved?
The short answer is no for consumer longevity or injury claims; verify any product-specific claim against official FDA records.
Jun 27, 20265 min readBPC-157 / FDA
Articles
Direct answers to high-intent longevity questions, with evidence labels and regulatory context up front.
24 briefings
RSSAnimal PreclinicalHighResearch Chemical
Does BPC-157 heal injuries in humans?
BPC-157 has animal and mechanism-heavy discussion, but that is not the same as strong human injury evidence.
Jun 27, 20265 min readBPC-157 / injury recovery
Mechanism OnlyDo Not Self AdministerResearch Chemical
What is TB-500 and how is it different from thymosin beta-4?
TB-500 is usually marketed as a peptide fragment related to thymosin beta-4, but naming can blur important evidence and quality questions.
Jun 27, 20265 min readTB-500 / thymosin beta-4
Regulatory SignalModerateCompounded Not Fda Approved
Are compounded peptides FDA-approved?
Compounding can be lawful in some circumstances, but compounded drugs themselves are not FDA-approved products.
Jun 27, 20265 min readcompounded peptides / FDA
Regulatory SignalModerateUnclear
What the FDA peptide review could change in 2026.
A regulatory review can affect what compounders, clinics and consumers can claim, but it does not create human efficacy evidence by itself.
Jun 27, 20265 min readFDA / peptide review
Commercial ClaimDo Not Self AdministerResearch Chemical
Research peptides: why purity, identity and sterility matter.
Before benefit claims, readers should ask whether the substance is what the label says and whether it is appropriate for human use.
Jun 27, 20265 min readresearch peptides / quality
Human RctHighOff Label
Does rapamycin slow aging in humans?
Rapamycin is one of the most discussed geroscience drugs, but human longevity evidence remains incomplete.
Jun 27, 20265 min readrapamycin / sirolimus
Human RctHighOff Label
What did the PEARL rapamycin trial actually show?
PEARL is important because it asks human questions, but readers should distinguish trial signals from sweeping longevity claims.
Jun 27, 20265 min readPEARL / rapamycin
Clinical Trial RegisteredModerateFda Approved For Other Use
Metformin for longevity: what TAME is trying to answer.
TAME is designed around whether one approved diabetes drug can affect multiple aging-related outcomes, but it is not a completed answer.
Jun 27, 20265 min readmetformin / TAME
Regulatory SignalModerateOff Label
What does off-label mean in longevity medicine?
Off-label use is common in medicine, but it should not be confused with approval for anti-aging claims.
Jun 27, 20265 min readoff-label / regulation
Human RctModerateSupplement
NMN vs NR: what is the difference?
Both NMN and NR are NAD-related precursors, but chemistry, regulation and human evidence need to be kept separate.
Jun 27, 20265 min readNMN / NR
Human RctModerateSupplement
Do NAD supplements slow aging?
NAD biology is real, but the leap from NAD markers to human aging outcomes is larger than most ads admit.
Jun 27, 20265 min readNAD / supplements
Commercial ClaimModerateUnclear
NAD IV drips: evidence, cost and unanswered questions.
IV NAD clinics sell a high-touch experience, but route of delivery does not solve the outcome-evidence problem.
Jun 27, 20265 min readNAD IV / clinics
UnknownModerateUnclear
The longevity stack problem: why combinations are hard to interpret.
When multiple interventions change at once, impressive stories become hard to assign to any one ingredient.
Jun 27, 20265 min readstacking / supplements
Mechanism OnlyDo Not Self AdministerInvestigational
Is age-reversal gene therapy real?
Gene therapy is real medicine in specific diseases; consumer age-reversal gene therapy is a much more speculative claim.
Jun 27, 20265 min readgene therapy / age reversal
Animal PreclinicalInvestigationalInvestigational
What is partial epigenetic reprogramming?
Partial reprogramming tries to reset aspects of cell state without erasing identity, but it remains frontier biology.
Jun 27, 20265 min readpartial reprogramming / epigenetics
Mechanism OnlyInvestigationalInvestigational
What are OSK factors?
OSK refers to three reprogramming factors often discussed in cellular rejuvenation research.
Jun 27, 20265 min readOSK / reprogramming factors
Regulatory SignalInvestigationalInvestigational
Approved gene therapy vs anti-aging gene therapy.
Approved gene therapies are specific products for specific diseases; anti-aging gene therapy claims need separate evidence and regulatory scrutiny.
Jun 27, 20265 min readgene therapy / FDA approval
Human ObservationalLowUnclear
What is biological age?
Biological age is an attempt to estimate health or aging state, not a second birth certificate.
Jun 27, 20265 min readbiological age / biomarkers
Human ObservationalLowUnclear
Are epigenetic clocks useful for individuals?
Epigenetic clocks can be powerful research tools, but personal interpretation is still a high-noise exercise.
Jun 27, 20265 min readepigenetic clocks / biological age
Human ObservationalLowUnclear
The longevity biomarker map: VO2 max, ApoB, CGM, DEXA and HRV.
Some biomarkers are clinically actionable, some are performance markers and some are exploratory signals.
Jun 27, 20265 min readVO2 max / ApoB
Mechanism OnlyModerateUnclear
What are senescent cells?
Senescent cells are part of aging biology, but they are not simply bad cells to eliminate everywhere.
Jun 27, 20265 min readsenescent cells / cellular aging
Animal PreclinicalHighInvestigational
What are senolytics?
Senolytics are interventions intended to remove certain senescent cells, but most longevity claims remain early.
Jun 27, 20265 min readsenolytics / fisetin
Human RctLowUnclear
What actually works in longevity before experimental interventions?
The strongest foundation is not exotic: fitness, blood pressure, lipids, sleep, smoking avoidance, nutrition and preventive care.
Jun 27, 20265 min readexercise / sleep